Research topics

This page will always be under construction… You will find here the current main projects, supported by students, grants, …

Our work is based on the study of mechanics and mechanotransduction of cells, mainly immune cells, in native or pathological situations. It can be divided in two main classes :

For T lymphocytes, we try to have a better, more integrated picture, of their early activation :

• Early T cell mechanotransduction with P. Pierobon, Cochin, J. Husson, LaDHyX, D. Gonzalez, Metz Univ. (ANR Criticality)
• T cell mechanostransduction & cholesterol with Y. Hamon, CIML, Marseille (Centuri PhD thesis)
• Lymphocyte early biophysical activation with K. Sengupta, CINaM, L. Limozin, LAI

For phagocytes, we try to understand how their target biophysical characteristics impact their action :

• Toxoplasma & Eimeria mechanics and adhesion, with A. Dumetre, Inserm U1067, Marseille (ANR BreakInTheWall) — http://toxophysics.wordpress.com/)

Aside, we participate in understanding how to tune the reaction of immune cells to pathological situations, in particular cancer :

• Antibody recognition, with L. Limozin, Inserm U1067, Marseille (ANR DNAnobodies)

We organize collective efforts at the interface between physics and immunology :

• CNRS IRP FR/MEX BioPhysImmuno on “Adhesion and mechanics in fibrosis, lymphocyte/cancer or lymphocyte/APC interactions”, with M. Hautefeuille, Sorbonne Univ. & T.Fioderlisio-Colle, UNAM, Mexico City, L. Limozin, LAI, K. Sengupta, CINAM — https://biophysimmuno.wordpress.com/

News ideas & new techniques are coming…